| Drug Name |
Anastrozole |
| Drug ID |
BADD_D00142 |
| Description |
Anastrozole is a non-steroidal aromatase inhibitor (AI), similar to [letrozole], used to decrease circulating estrogen levels in the treatment of postmenopausal women with estrogen-responsive breast cancer.[L8863] Anastrozole is also related to [exemestane], a steroidal AI, but its non-steroidal nature provides stark advantages including a lack of steroid-associated adverse effects such as weight gain and acne.[A186865] Aromatase inhibitors, including anastrozole, have become endocrine drugs of choice in the treatment of postmenopausal breast cancer due to a more favourable efficacy and adverse effect profile as compared to earlier estrogen receptor modulators such as [tamoxifen].[A186877,A186955]
Anastrozole was first approved for use in the United States in 1995.[L8863] |
| Indications and Usage |
For adjuvant treatment of hormone receptor positive breast cancer , as well as hormonal treatment of advanced breast cancer in post-menopausal women. Has also been used to treat pubertal gynecomastia and McCune-Albright syndrome; however, manufacturer states that efficacy for these indications have not been established. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
L02BG03 |
| DrugBank ID |
DB01217
|
| KEGG ID |
D00960
|
| MeSH ID |
D000077384
|
| PubChem ID |
2187
|
| TTD Drug ID |
D0W0BF
|
| NDC Product Code |
63850-6527; 0395-8157; 68554-0026; 0310-0201; 71335-1879; 65129-1119; 16729-035; 68071-1682; 71052-248; 72789-008; 65096-0117; 51991-620; 59651-236; 65072-0702; 63629-5269; 16571-421; 63850-0010; 82393-201; 62135-490; 63187-080; 62559-670; 50090-2453; 58623-0041; 55111-814; 68382-209; 51927-4435; 68001-155; 50090-5002; 65841-743; 76420-004; 50268-075; 0093-7536; 61200-104; 42291-085; 46014-1160; 70518-2484; 73377-120; 69988-0013; 50090-5812; 62756-428; 62157-077; 70934-488; 70518-2420; 60429-286; 68071-5203; 60687-112; 51552-1568; 46014-1009; 38779-2555; 0904-6195; 43063-383; 60440-2921; 53104-7627; 62175-710 |
| Synonyms |
Anastrozole | 2,2'-(5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropionitrile) | Anastrazole | Arimidex | ICI D1033 | ZD-1033 | ZD 1033 | Zeneca ZD 1033 | ZD1033 |
