Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amoxicillin
Drug ID BADD_D00129
Description Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972.[A190648] Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin.[A190648] Amoxicillin was granted FDA approval on 18 January 1974.[L11644]
Indications and Usage For the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of Streptococcus spp. (a- and b-hemolytic strains only), S. pneumoniae, Staphylococcus spp., H. influenzae, E. coli, P. mirabilis, or E. faecalis. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to N. gonorrhoeae (males and females).
Marketing Status Prescription; Discontinued
ATC Code J01CA04
DrugBank ID DB01060
KEGG ID D00229
MeSH ID D000658
PubChem ID 33613
TTD Drug ID D0F6EO
NDC Product Code 16714-299; 63187-729; 68071-2323; 67296-1126; 70882-114; 63187-335; 50090-0407; 70518-1413; 70934-672; 50090-1826; 65862-016; 72789-225; 72789-077; 63187-186; 72189-285; 55657-106; 0093-3109; 68071-1526; 68071-4734; 45865-594; 65862-707; 68788-9949; 68071-1675; 50090-1794; 67296-1659; 61919-716; 68071-1817; 70847-530; 70882-113; 61919-041; 63187-044; 16714-298; 68071-4548; 50090-4260; 72508-205; 68071-2364; 63187-043; 68788-7318; 68071-4953; 65862-014; 50090-1797; 68071-2397; 65862-071; 52115-001; 65862-015; 0143-9889; 63187-200; 50090-4929; 63629-7585; 57237-033; 50090-1513; 70518-2191; 68071-4851; 68071-4704; 0143-9887; 50090-2251; 0781-5061; 63187-343; 0143-9886; 55289-182; 68071-4920; 70518-2188; 53002-1369; 68071-4567; 68071-4982; 50090-4320; 43063-820; 70934-064; 53002-2160; 0143-9888; 65862-274; 63629-7582; 71205-266; 63629-7584; 0093-4160; 50090-1795; 66267-871; 50090-0404; 0093-4161; 53002-0130; 50090-1807; 68071-1760; 0143-9938; 59115-041; 0143-9939; 68071-4907; 71205-507; 68788-7414; 76420-003; 65862-706; 0781-6156; 67296-1156; 68071-5019; 68071-4064; 63187-262; 68071-4455; 63187-195; 70518-3234; 43063-341; 68071-4574; 0781-5060; 72789-075; 61919-401; 65862-017; 68071-5127; 0781-6041; 57237-028; 43063-563; 68788-9017; 53002-2091; 70518-2190; 50090-0713; 63187-027; 68071-3292; 68071-4698; 68071-2604; 50090-3516; 43063-915; 70518-3228; 50090-1086; 63629-7587; 50090-1347; 53002-2080; 0093-2264; 70847-550; 68788-9948; 68071-2423; 63187-029; 68788-6374; 0093-2267; 68071-2558; 71205-422; 0781-6157; 70518-3294; 42708-112; 50090-1511; 50090-0712; 50090-1796; 55289-020; 43063-574; 50090-0709; 72789-074; 50090-0858; 68071-1789; 57237-030; 68071-4468; 68071-1761; 68071-3343; 63629-7589; 68071-4581; 70934-054; 70934-038; 70934-033; 0781-2613; 42708-078; 70934-087; 57237-031; 61919-015; 0093-3107; 54348-550; 55657-101; 61919-623; 72789-078; 63187-399; 66267-993; 68788-9019; 55289-019; 0781-2020; 71205-035; 42708-076; 68071-2320; 50090-0301; 71205-177; 50090-1595; 76420-138; 0093-2268; 53002-2090; 50090-1512; 0143-9285; 61919-994; 72789-224; 50090-1596; 68071-5148; 68788-7141; 68071-4971; 50090-0303; 66267-994; 50090-0405; 63187-880; 71205-436; 68071-4086; 0093-2263; 42708-010; 70934-140; 68788-6369; 61919-135; 50090-5863; 68788-9018; 57237-029; 50090-0455; 61919-672; 70934-084; 76420-192; 68071-4969; 65862-070; 72508-225; 70934-310; 68071-5096; 68071-5109; 50090-4078; 59651-099; 67296-0986; 68071-4741; 50090-5880; 63629-7588; 50090-4325; 70934-154; 50090-0711; 63187-013; 63187-295; 68071-4796; 43063-885; 0093-4155; 76420-112; 50090-0714; 57237-032; 63187-325; 68071-4693; 50090-0406; 43063-017; 68788-7812; 0781-6039; 50090-1514; 63187-591; 70934-407; 68071-3119; 50090-5215; 50090-0411; 68071-1826; 68071-4724; 68788-7323; 50090-0288; 68071-4696
Synonyms Amoxicillin | Amoxycillin | Amoxicilline | Amoxicillin Monopotassium Salt | Hydroxyampicillin | Amoxicillin Sodium | Amoxicillin Monosodium Salt | Amoxicillin, (R*)-Isomer | Amoxicillin Anhydrous | Actimoxi | BRL-2333 | BRL 2333 | BRL2333 | Clamoxyl | Penamox | Clamoxyl Parenteral | Clamoxyl G.A. | Polymox | Trimox | Wymox | Amoxicillin Trihydrate | Amoxil
Chemical Information
Molecular Formula C16H19N3O5S
CAS Registry Number 26787-78-0
SMILES CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HyperphosphatasaemiaC-C chemokine receptor type 4P51679T0695525998949
HyperphosphatasaemiaC-X-C chemokine receptor type 3P49682T2531525998949
HyperphosphatasaemiaC-C chemokine receptor type 9P51686T9787325998949
Liver injuryC-X-C chemokine receptor type 3P49682T2531525998949
Liver injuryC-C chemokine receptor type 9P51686T9787325998949
Liver injuryC-C chemokine receptor type 4P51679T0695525998949
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fear19.06.03.001--Not Available
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.008--Not Available
Feeling hot08.01.09.0090.000232%Not Available
Fibrosis08.03.01.0010.000020%Not Available
Fixed drug eruption23.03.05.006; 10.01.01.022; 08.01.06.0170.000111%Not Available
Flank pain08.01.08.007; 20.02.03.006; 15.03.04.0030.000020%
Flatulence07.01.04.002--
Flushing23.06.05.003; 24.03.01.002; 08.01.03.0250.000192%
Frequent bowel movements07.02.04.002--Not Available
Fungal infection11.03.05.001--Not Available
Gait disturbance08.01.02.002; 17.02.05.016--
Gallbladder disorder09.03.02.001--Not Available
Gamma-glutamyltransferase increased13.03.01.0110.000081%
Gastrooesophageal reflux disease07.02.02.003--
Gastroenteritis11.01.07.004; 07.19.03.0010.000091%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.0050.000061%
Generalised oedema14.05.06.007; 08.01.07.0040.000061%
Generalised tonic-clonic seizure17.12.01.002--Not Available
Gingival bleeding07.09.07.001; 24.07.02.010--Not Available
Gingival pain07.09.04.0010.000030%
Gingivitis11.01.04.013; 07.09.03.0030.000030%
Glossitis07.14.01.001--Not Available
Haematemesis07.12.02.002; 24.07.02.0110.000061%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.000081%Not Available
Haematoma24.07.01.001--
Haematuria24.07.01.047; 20.02.01.0060.000172%
Haemoglobin13.01.05.018--Not Available
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