Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amlodipine besylate
Drug ID BADD_D00122
Description Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers [A175327]. Amlodipine is commonly used in the treatment of high blood pressure and angina. Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure [A175321]. The option for single daily dosing of amlodipine is an attractive feature of this drug [FDA label].
Indications and Usage For the treatment of hypertension and chronic stable angina.
Marketing Status Prescription; Discontinued
ATC Code C08CA01
DrugBank ID DB00381
KEGG ID D00615
MeSH ID D017311
PubChem ID 60496
TTD Drug ID D08JIV
NDC Product Code 65862-103; 43489-101; 50090-2524; 43489-102; 71335-1887; 63187-197; 53808-1100; 59762-2242; 69097-837; 70934-920; 65841-622; 0832-0042; 68180-720; 60687-496; 71205-599; 71205-488; 65977-0005; 61919-782; 68788-7985; 42806-056; 65162-007; 71335-1597; 71859-001; 55289-103; 66174-0020; 53104-7561; 12634-562; 53002-2351; 59762-2135; 51552-1438; 63629-8023; 70934-434; 0615-8283; 42806-057; 38779-2734; 70518-1971; 61919-805; 53002-2352; 67877-199; 68788-6386; 65841-621; 68382-122; 65427-003; 59762-2010; 0615-8282; 29300-398; 67877-197; 13668-023; 61919-753; 71205-506; 63187-914; 43489-100; 65862-101; 67877-198; 71610-469; 67296-1530; 0832-0044; 76282-507; 68788-7259; 68724-0008; 71335-0946; 67296-1529; 71335-0799; 71335-0218; 55700-541; 72789-082; 70934-075; 76282-509; 43353-989; 55154-6892; 29300-241; 68382-123; 69097-836; 69584-021; 50090-4903; 69097-126; 53002-1249; 43063-564; 70518-0376; 63629-6631; 69584-022; 29300-242; 57451-1188; 65162-008; 61919-814; 43063-041; 43353-251; 0904-6370; 48581-300; 68788-9345; 58159-068; 71205-596; 43063-764; 42185-7058; 51927-0012; 13668-022; 69150-114; 68071-1903; 63629-7640; 55111-025; 61919-460; 68071-2270; 71335-1761; 60760-132; 76282-238; 71335-1865; 71052-266; 0904-6369; 50090-5059; 0143-9959; 50090-5354; 61919-295; 68645-515; 51655-052; 52932-0723; 12634-599; 60760-614; 55700-738; 63187-783; 76282-508; 71335-0945; 29300-243; 42582-314; 0615-8284; 52605-042; 68788-7679; 68071-1974; 69150-115; 42582-313; 63187-326; 60687-488; 29300-397; 76282-237; 68180-719; 71335-0843; 71335-0890; 52605-041; 71093-147; 70518-0274; 71335-1278; 68071-3188; 51927-0073; 65862-344; 68645-580; 50090-1529; 71335-0389; 50090-5355; 71335-0473; 68071-4251; 53002-2249; 68382-121; 50090-1527; 65162-006; 0904-6371; 65862-102; 70934-288; 43353-691; 61919-844; 53002-3351; 42806-055; 69150-113; 0143-9960; 70934-067; 52605-043; 65691-0040; 0143-9961; 67296-1648; 63187-198; 69097-838; 68071-1924; 70518-1914; 68071-1980; 68180-721; 0069-1540; 53002-1351; 67046-036; 0395-8092; 65841-014; 71610-535; 55154-8093; 68071-1348; 69584-023; 57218-936; 71093-148; 50090-1404; 69097-127; 55700-543; 64220-183; 69097-128; 0832-0043; 43353-684; 0069-1520; 50090-1627; 42708-066; 0069-1530; 70518-2981; 65841-620; 71335-0833; 71093-146; 49452-0429; 13668-024; 68071-4776; 71610-539; 60760-445; 63629-1023; 63187-508; 68071-2415; 68981-016; 53002-1352; 53747-011; 65015-670; 60760-459; 55154-6875; 76282-239; 70518-0835; 67046-684; 70518-2632; 42582-315; 53002-3249; 50090-5049; 72189-162; 68071-5151; 70934-330; 29300-396; 71335-1032; 58118-1127; 50090-2581; 68645-516; 68071-2520; 71335-0934; 63629-1024; 71610-620
Synonyms Amlodipine | Amlodipine, (+-)-Isomer | Amlodipine Besylate | Amlodipine, (+-)-Isomer, Maleate (1:1) | Amlodipine, (S)-Isomer, Maleate (1:1) | Amlodis | Astudal | Norvasc | Istin | Amlor | Amlodipine Maleate | Amlodipine Maleate (1:1) | Amlodipine, (R)-Isomer
Chemical Information
Molecular Formula C26H31ClN2O8S
CAS Registry Number 111470-99-6
SMILES CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vasculitis24.05.02.001; 10.02.02.006--
Ventricular tachycardia02.03.04.010--
Vertigo17.02.12.002; 04.04.01.003--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Xerophthalmia06.06.03.008; 14.12.03.002--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Lymphatic disorder01.09.01.003--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Affect lability19.04.01.001--Not Available
Female sexual dysfunction21.03.02.004; 19.08.05.001--Not Available
Male sexual dysfunction21.03.02.012; 19.08.05.003--Not Available
Angiopathy24.03.02.007--Not Available
Urine output increased13.13.03.002--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Ill-defined disorder08.01.03.049--Not Available
Inner ear disorder04.04.02.002--Not Available
Blood disorder01.05.01.004--Not Available
Candida infection11.03.03.021--
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