| Drug Name |
Amlodipine |
| Drug ID |
BADD_D00121 |
| Description |
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers [A175327].
Amlodipine is commonly used in the treatment of high blood pressure and angina. Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure [A175321]. The option for single daily dosing of amlodipine is an attractive feature of this drug [FDA label]. |
| Indications and Usage |
For the treatment of hypertension and chronic stable angina. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
C08CA01 |
| DrugBank ID |
DB00381
|
| KEGG ID |
D07450
|
| MeSH ID |
D017311
|
| PubChem ID |
2162
|
| TTD Drug ID |
D08JIV
|
| NDC Product Code |
52652-5001; 46287-035 |
| Synonyms |
Amlodipine | Amlodipine, (+-)-Isomer | Amlodipine Besylate | Amlodipine, (+-)-Isomer, Maleate (1:1) | Amlodipine, (S)-Isomer, Maleate (1:1) | Amlodis | Astudal | Norvasc | Istin | Amlor | Amlodipine Maleate | Amlodipine Maleate (1:1) | Amlodipine, (R)-Isomer |
