Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Aminophylline dihydrate
Drug ID BADD_D00113
Description Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic bronchitis, and COPD. The majority of aminophylline medications are discontinued and the remaining medications on the market are in short supply.
Indications and Usage For the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
Marketing Status Prescription; Discontinued
ATC Code R03DA05
DrugBank ID DB01223
KEGG ID D11630
MeSH ID D000628
PubChem ID 20848874
TTD Drug ID D03TYI
NDC Product Code 52584-921; 51662-1204; 71872-7060; 51662-1341; 52584-922; 0409-5921; 0409-5922; 0404-9814; 0395-8156; 43744-019; 71872-7121; 58624-0544; 0404-9813
Synonyms Aminophylline | Theophylline Ethylenediamine | Ethylenediamine, Theophylline | Theophyllamine | Phyllotemp | Mundiphyllin | Theophyllamin Jenapharm | Theophyllin EDA-ratiopharm | Theophyllin EDA ratiopharm | Theophyllin EDAratiopharm | Truphylline | Afonilum | Carine | Eufilina | Euphyllin | Aminodur | Aminophyllin | Aminophylline DF | Cardophyllin | Clonofilin | Corophyllin | Diaphyllin | Drafilyn | Duraphyllin | Eufilina Venosa | Euphyllin Retard | Euphylline | Godafilin | Mini-Lix | Mundiphyllin Retard | Novophyllin | Phyllocontin | Somophyllin | Tari-Dog
Chemical Information
Molecular Formula C16H28N10O6
CAS Registry Number 5897-66-5
SMILES CN1C2=C(C(=O)N(C1=O)C)NC=N2.CN1C2=C(C(=O)N(C1=O)C)NC=N2.C(CN)N.O.O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acid base balance abnormal13.02.01.001--Not Available
Atrial fibrillation02.03.03.002--
Atrial flutter02.03.03.003--
Atrial tachycardia02.03.03.004--
Death08.04.01.001--
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hypokalaemia14.05.03.002--
Hypotension24.06.03.002--
Nervousness19.06.02.003--Not Available
Rhabdomyolysis15.05.05.002--
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Sinus tachycardia02.03.03.010--
Supraventricular tachycardia02.03.03.012--
Tremor17.01.06.002--
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.007--Not Available
Vomiting07.01.07.003--
Haemodynamic instability24.03.02.006--Not Available
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