Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amantadine
Drug ID BADD_D00097
Description An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.
Indications and Usage For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.
Marketing Status Prescription; Discontinued
ATC Code N04BB01
DrugBank ID DB00915
KEGG ID D07441
MeSH ID D000547
PubChem ID 2130
NDC Product Code 62332-246; 68025-076; 70482-085; 70482-170; 68025-075; 60687-422; 70482-075; 11014-0234; 46708-246; 11014-0245; 68025-074; 70482-076; 62332-586; 46708-586
Synonyms Amantadine | 1-Aminoadamantane | 1 Aminoadamantane | Adamantylamine | Wiregyt | Amanta | Amanta-HCI-AZU | Amanta HCI AZU | AmantaHCIAZU | Amanta-Sulfate-AZU | Amanta Sulfate AZU | AmantaSulfateAZU | Amantadin AZU | AZU, Amantadin | Amantadin AL | AL, Amantadin | Amantadin Stada | Stada, Amantadin | Amantadin-neuraxpharm | Amantadin neuraxpharm | Amantadinneuraxpharm | Amantadin-ratiopharm | Amantadin ratiopharm | Amantadinratiopharm | Amantadina Juventus | Juventus, Amantadina | Amantadina Llorente | Llorente, Amantadina | Amantadine Hydrochloride | Hydrochloride, Amantadine | Amantadine Sulfate | Sulfate, Amantadine | Amixx | Cerebramed | Gen-Amantadine | Gen Amantadine | GenAmantadine | Infecto-Flu | Infecto Flu | InfectoFlu | Infex | Midantan | PMS-Amantadine | PMS Amantadine | PMSAmantadine | Symadine | Symmetrel | Endantadine | Mantadix | tregor | Viregyt | Adekin | Aman
Chemical Information
Molecular Formula C10H17N
CAS Registry Number 768-94-5
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute respiratory failure22.02.06.001; Available
Aggression19.05.01.001--Not Available
Agranulocytosis01.02.03.001--Not Available
Anaphylactic shock24.06.02.004; Available
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Blindness unilateral17.17.01.016; Available
Body temperature decreased13.15.01.010--Not Available
Body temperature increased13.15.01.001--Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Coma17.02.09.001--Not Available
Completed suicide19.12.01.001; Available
Confusional state19.13.01.001;
Corneal oedema06.04.02.0010.001802%Not Available
Corneal opacity06.06.03.005--Not Available
Depressed level of consciousness17.02.04.002--
Dermatitis23.03.04.002--Not Available
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