Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alvimopan
Drug ID BADD_D00096
Description Alvimopan is a peripherally acting μ opioid antagonist. It is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period.
Indications and Usage Used to accelerate the time to upper and lower gastrointestinal recovery following partial large or small bowel resection surgery with primary anastomosis. Also investigated for use in the treatment of pain (acute or chronic).
Marketing Status Prescription
ATC Code A06AH02
DrugBank ID DB06274
KEGG ID D02878
MeSH ID C419502
PubChem ID 5488548
TTD Drug ID D0D7KC
NDC Product Code 0591-2312; 67919-020; 55679-111
Synonyms alvimopan | trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine | alvimopan anhydrous | anhydrous alvimopan | LY 246736 | LY246736 | LY-246736 | ADL 8-2698 | ADL8-2698 | Entereg
Chemical Information
Molecular Formula C25H32N2O4
CAS Registry Number 156053-89-3
SMILES CC1CN(CCC1(C)C2=CC(=CC=C2)O)CC(CC3=CC=CC=C3)C(=O)NCC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaemia01.03.02.001--
Back pain15.03.04.005--
Constipation07.02.02.001--
Dyspepsia07.01.02.001--
Flatulence07.01.04.002--
Gastrointestinal disorder07.11.01.001--Not Available
Hypokalaemia14.05.03.002--
Urethral disorder20.07.01.002--Not Available
Urinary retention20.02.02.011--
Urinary tract disorder20.08.01.001--Not Available
Lymphatic disorder01.09.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Malnutrition14.03.02.004--Not Available
Blood disorder01.05.01.004--Not Available
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