Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cystocele21.07.05.004; 20.03.01.0150.001111%Not Available
Deafness04.02.01.0010.002122%Not Available
Deafness neurosensory17.04.07.001; 04.02.01.0020.000808%Not Available
Death08.04.01.001--
Decreased activity19.11.01.002; 08.01.01.0060.000202%Not Available
Decubitus ulcer23.03.11.0060.000909%Not Available
Dehydration14.05.05.0010.004142%
Delirium19.13.02.0010.001111%
Dementia19.20.02.001; 17.03.01.0010.002223%Not Available
Dementia Alzheimer's type19.20.03.001; 17.03.06.0010.000606%Not Available
Dental caries07.09.01.0010.009295%
Depressed level of consciousness17.02.04.002--
Depressed mood19.15.02.001--Not Available
Depression19.15.01.0010.022632%
Dermal cyst23.10.02.001; 16.26.02.0010.001313%Not Available
Dermatitis23.03.04.0020.001212%Not Available
Dermatitis allergic23.03.04.003; 10.01.03.0140.001414%Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.0030.002021%Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.0040.000202%
Diabetes mellitus14.06.01.001; 05.06.01.0010.004446%Not Available
Diabetes mellitus inadequate control14.06.01.004; 05.06.01.0040.001111%Not Available
Diabetic neuropathy17.09.04.002; 14.07.04.003; 05.07.04.0030.000707%Not Available
Diabetic retinopathy24.03.07.004; 14.07.01.002; 06.10.02.002; 05.07.01.0020.000202%Not Available
Diaphragmatic hernia22.09.02.001; 07.16.01.0020.000202%Not Available
Diarrhoea07.02.01.001--
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.0020.000202%Not Available
Dilatation atrial02.04.02.0190.000202%Not Available
Dilatation ventricular02.04.02.0260.000202%Not Available
Diplopia17.17.01.005; 06.02.06.0020.000909%Not Available
Discomfort08.01.08.003--Not Available
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