Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Osteomyelitis bacterial15.02.05.009; 11.02.01.0440.000202%Not Available
Dental fistula11.01.04.017; 07.11.05.0080.000606%Not Available
Medial tibial stress syndrome15.02.04.0360.000202%Not Available
Ligament rupture12.01.07.014; 15.07.02.0080.001111%Not Available
Oral cavity fistula07.11.05.0140.001414%
Avulsion fracture12.04.02.012; 15.08.02.0100.000404%Not Available
Stress urinary incontinence20.02.02.0220.002324%Not Available
Bone contusion12.01.08.041; 24.07.06.019; 15.02.04.0250.000404%Not Available
Retroperitoneal lymphadenopathy07.07.01.012; 01.09.01.0290.000202%Not Available
Carotid arteriosclerosis24.04.06.031; 17.08.02.0150.000303%Not Available
Fistula discharge15.03.02.015; 08.01.03.0690.001212%Not Available
Right atrial dilatation02.04.02.0320.000202%Not Available
Left atrial dilatation02.04.02.0250.000707%Not Available
Osteoradionecrosis24.04.05.012; 15.02.04.037; 12.05.02.0110.000202%Not Available
Quality of life decreased13.18.01.0130.004547%Not Available
Heart valve incompetence02.07.02.0030.000303%Not Available
Reflux laryngitis22.04.01.0070.000303%Not Available
Bone abscess15.02.05.005; 11.01.01.0060.000303%Not Available
Bone density abnormal13.16.01.0050.000202%Not Available
Periprosthetic fracture12.02.13.003; 15.08.02.0150.002425%Not Available
Vertebral foraminal stenosis17.10.01.024; 15.01.08.0150.001819%Not Available
Klebsiella test positive13.08.01.0110.000202%Not Available
Helicobacter test positive13.08.01.0100.000404%Not Available
Pubis fracture12.04.06.004; 15.08.06.0040.003334%Not Available
Limb asymmetry15.10.03.0090.004041%
Cerebral small vessel ischaemic disease24.04.06.034; 17.08.02.0200.000505%Not Available
Bone deformity15.10.03.0060.000404%Not Available
Exposed bone in jaw15.02.04.0340.002324%Not Available
Soft tissue mass15.03.02.0190.000404%Not Available
Infected dermal cyst23.10.02.002; 16.26.02.002; 11.01.12.0240.000202%Not Available
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