Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Jaw fistula15.02.04.045; 07.11.05.0210.000066%Not Available
Joint noise15.01.02.0120.000264%Not Available
Laryngeal ulceration22.04.01.0140.000044%Not Available
Lip neoplasm07.21.08.003; 16.13.09.0030.000044%Not Available
Lipoma of breast21.05.01.031; 16.14.01.0080.000066%Not Available
Loose body in joint15.01.02.0130.000088%Not Available
Mandibular mass15.03.05.021; 08.03.05.0110.000044%Not Available
Medical device pain08.07.01.0160.000220%Not Available
Myofascial spasm15.05.03.039; 17.05.03.0200.000044%Not Available
Myxoid cyst23.03.03.093; 15.04.02.0060.000044%Not Available
Oesophageal hypomotility07.02.02.021--Not Available
Oral fibroma16.05.04.004; 07.20.02.0050.000044%Not Available
Osteochondritis15.07.03.0090.000044%Not Available
Osteoporosis postmenopausal21.02.02.006; 15.02.03.020; 14.04.04.0190.000044%Not Available
Ovarian calcification21.11.02.0210.000044%Not Available
Pelvic organ prolapse21.07.04.0160.000044%Not Available
Pharyngeal swelling22.04.05.028--Not Available
Pinguecula06.06.02.0130.000044%Not Available
Pulmonary hilum mass22.09.03.0150.000044%Not Available
Pulpless tooth07.09.12.0020.000154%Not Available
Salivary gland adenoma16.05.04.006; 07.20.02.0070.000044%Not Available
Senile osteoporosis14.04.04.021; 15.02.03.0220.000066%Not Available
Spinal claudication24.04.06.050; 17.10.01.0300.000044%Not Available
Spinal meningeal cyst17.18.05.006; 16.09.05.0060.000044%Not Available
Spinal stenosis17.10.01.031; 15.10.04.0140.001343%Not Available
Surgical failure08.06.01.0490.000088%Not Available
Tongue neoplasm benign07.20.02.008; 16.05.04.0070.000044%Not Available
Traumatic occlusion07.09.05.0190.000044%Not Available
Tympanosclerosis04.05.04.0040.000044%Not Available
Uterine cervix atrophy21.06.01.0200.000044%Not Available
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