Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intervertebral disc space narrowing15.10.01.0070.000088%Not Available
Bursa disorder15.04.01.0020.000088%Not Available
Tenosynovitis stenosans15.07.01.0130.000132%Not Available
Bone formation decreased15.02.04.0280.000132%Not Available
Dental plaque07.09.02.0020.000066%Not Available
Gastrointestinal tract mucosal pigmentation07.11.03.0090.000088%Not Available
Biliary dilatation09.02.03.0040.000088%Not Available
Adenoidal disorder22.04.05.0140.000176%Not Available
Aortic dilatation24.03.04.0070.000066%Not Available
Subacute cutaneous lupus erythematosus15.06.02.012; 10.04.03.012; 23.03.02.0200.000044%Not Available
Hypertensive emergency24.08.01.0040.000066%Not Available
Bladder mass20.03.01.0180.000044%Not Available
Ovarian mass21.11.02.0170.000044%Not Available
Spinal deformity15.10.04.0100.000154%Not Available
Desmoid tumour16.18.01.006; 15.09.01.0050.000044%Not Available
Parophthalmia06.04.11.0030.000207%Not Available
Lung hyperinflation22.12.01.0050.000066%Not Available
Renal cyst haemorrhage24.07.07.003; 20.01.04.017; 16.27.01.0050.000044%Not Available
Appendix disorder07.11.01.0200.000682%Not Available
Arterial haemorrhage24.07.01.0630.000044%Not Available
Arterial stenosis24.04.02.0120.000044%Not Available
Foot deformity15.10.03.0050.001189%Not Available
Hip deformity15.10.03.0080.000110%Not Available
Ligament disorder15.07.02.0020.000088%Not Available
Malocclusion07.09.05.0130.000066%Not Available
Mastoid disorder04.05.05.0020.000110%Not Available
Facial nerve disorder17.04.03.0060.000044%
Oesophageal squamous cell carcinoma16.13.06.004; 07.21.06.0040.000044%Not Available
Aortic valve disease02.07.03.0020.000066%
Deformity08.01.03.0220.000088%Not Available
The 35th Page    First    Pre   35 36 37 38 39    Next   Last    Total 39 Pages