Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anal incontinence17.05.01.021; 07.01.06.0290.000132%
Frustration tolerance decreased19.04.02.0160.000066%Not Available
Persistent depressive disorder19.15.01.0060.000088%Not Available
Ureterolithiasis20.04.03.0030.000066%Not Available
Somatic symptom disorder19.24.01.0060.000427%Not Available
Abdominal mass07.01.01.0030.000044%Not Available
Abnormal loss of weight14.03.02.0190.000066%Not Available
Adjustment disorder with depressed mood19.23.01.0020.000088%Not Available
Anaemia of chronic disease01.03.04.0020.000330%Not Available
Antiphospholipid syndrome24.01.01.029; 18.02.04.002; 10.04.01.009; 01.01.02.0160.000044%Not Available
Astigmatism06.02.04.0090.000176%Not Available
Bone cyst15.02.04.026; 16.11.03.0010.000242%Not Available
Bone formation increased15.02.04.0290.000110%Not Available
Borderline glaucoma06.03.01.0050.000088%Not Available
Breast cancer in situ21.05.01.015; 16.10.01.0070.000088%Not Available
Breast cancer recurrent21.05.01.017; 16.10.01.0090.000088%Not Available
Cardiac aneurysm24.02.02.004; 02.04.02.0300.000044%Not Available
Cervical cord compression17.10.02.0020.000044%Not Available
Cervical spinal stenosis17.10.02.006; 15.10.04.0060.000176%Not Available
Chondromalacia15.01.08.0090.000198%Not Available
Coeliac disease14.02.01.007; 10.04.04.012; 07.17.01.0080.000154%Not Available
Dumping syndrome12.02.03.017; 07.01.06.0310.000044%Not Available
Enthesopathy15.07.01.0110.000088%Not Available
Exostosis of jaw15.02.04.0330.000484%Not Available
Fear of disease19.06.03.0070.001101%Not Available
Fracture delayed union15.08.01.002; 12.04.02.0150.001145%Not Available
Fracture malunion15.08.01.0030.000286%Not Available
Fracture nonunion12.04.02.017; 15.08.01.0040.003610%Not Available
Gliosis17.06.01.0040.000044%Not Available
Grief reaction19.23.01.0030.000066%Not Available
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