Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Basal cell carcinoma23.08.02.001; 16.03.02.0010.000704%Not Available
Benign breast neoplasm21.05.01.009; 16.14.01.0050.000154%Not Available
Benign neoplasm of skin23.10.01.006; 16.26.01.0060.000110%Not Available
Benign prostatic hyperplasia21.04.02.0010.000154%Not Available
Bile duct stone09.02.02.0030.000066%Not Available
Bladder dilatation20.03.01.0070.000044%Not Available
Bladder discomfort20.02.02.0190.000097%Not Available
Bladder neoplasm20.03.04.002; 16.08.03.0020.000088%Not Available
Bladder pain20.02.02.0010.000044%Not Available
Blepharitis23.03.04.012; 06.04.04.0010.000198%Not Available
Blindness06.02.10.003; 17.17.01.0030.000242%Not Available
Blindness unilateral06.02.10.007; 17.17.01.0160.000066%Not Available
Blister23.03.01.001; 12.01.06.0020.000374%Not Available
Body temperature increased13.15.01.001--Not Available
Bone development abnormal15.02.04.0030.000066%Not Available
Bone disorder15.02.04.0040.009611%Not Available
Bone neoplasm16.29.01.001; 15.09.02.0010.000044%Not Available
Bone pain15.02.01.0010.002060%
Bradycardia02.03.02.0020.000440%Not Available
Breast cancer21.05.01.003; 16.10.01.0010.001123%Not Available
Breast cyst21.05.01.006; 16.14.01.0040.000154%Not Available
Breast disorder female21.05.04.0070.000044%Not Available
Breast enlargement21.05.04.0010.000044%Not Available
Breast hyperplasia21.05.01.0070.000044%Not Available
Breast mass21.05.04.0020.000572%Not Available
Breast pain21.05.05.0030.000088%
Breath odour07.01.06.0020.000044%Not Available
Bronchiectasis22.03.02.0050.000044%Not Available
Bronchitis chronic22.03.01.0190.000198%Not Available
Bronchospasm22.03.01.004; 10.01.03.0120.000132%
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