Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Transaminases increased13.03.04.036--Not Available
Cerebral disorder17.02.10.0170.000088%Not Available
Metaplasia08.03.04.0040.000088%Not Available
Hypertensive nephropathy24.08.05.003; 20.01.08.0040.000066%Not Available
Haemorrhage24.07.01.002--Not Available
Postmenopausal haemorrhage21.02.01.002; 24.07.03.0020.000198%Not Available
Faecaloma07.01.03.0040.000110%Not Available
Pulmonary mass22.02.07.0040.000625%Not Available
Vulvovaginal pruritus23.03.12.009; 21.08.02.0040.000110%Not Available
Peripheral sensorimotor neuropathy17.09.03.0090.000044%Not Available
Colitis microscopic07.08.01.0110.000132%Not Available
Impaired fasting glucose14.06.02.004; 05.06.02.0040.000066%Not Available
Temperature intolerance08.01.09.0220.000176%Not Available
Urine odour abnormal20.02.01.0200.000110%Not Available
Hypoaesthesia oral17.02.06.021; 07.05.05.0030.000132%Not Available
Paraesthesia oral07.05.05.035; 17.02.06.0080.000044%Not Available
Paranasal sinus hypersecretion22.04.06.0040.000097%Not Available
Breast cancer female21.05.01.011; 16.10.01.0040.000066%Not Available
Anxiety disorder19.06.01.0020.000330%Not Available
Bipolar disorder19.16.01.0030.000154%Not Available
Major depression19.15.01.0030.000286%Not Available
Nicotine dependence19.07.06.0170.000066%Not Available
Dyslipidaemia14.08.04.0150.000947%Not Available
Cystoid macular oedema12.02.02.005; 06.04.06.0100.000044%Not Available
Dysplasia08.03.04.0070.000044%Not Available
Hypogonadism21.03.02.010; 05.05.04.0020.000044%Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.000176%Not Available
Aortic disorder24.03.04.0040.000088%Not Available
Thyroid mass05.02.01.0030.000044%Not Available
Restless legs syndrome17.02.07.008; 15.05.03.0120.000977%Not Available
The 27th Page    First    Pre   27 28 29 30 31    Next   Last    Total 39 Pages