Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Large intestine polyp16.05.02.006; 07.20.01.0100.001343%Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.0150.000044%Not Available
Vascular calcification24.03.02.0130.000330%Not Available
Metabolic syndrome14.06.02.007; 05.06.02.007; 24.08.02.0140.000198%Not Available
Fallopian tube disorder21.11.02.0020.000088%Not Available
Ear discomfort04.03.01.0050.000044%Not Available
Ear pruritus04.03.01.0110.000119%Not Available
Eye pruritus06.04.05.0060.000066%Not Available
Ocular discomfort06.08.03.0080.000097%Not Available
Respiratory tract congestion22.02.07.0030.000066%Not Available
Dystrophic calcification08.03.04.0090.000044%Not Available
Diastolic dysfunction02.04.02.0220.000242%Not Available
Nasal discomfort22.12.03.0120.000119%Not Available
Paranasal sinus discomfort22.12.03.0180.000066%Not Available
Deafness bilateral04.02.01.0070.000066%Not Available
Urticaria chronic23.04.02.009; 10.01.06.0090.000044%Not Available
Oral pruritus07.05.05.0020.000044%Not Available
Musculoskeletal stiffness15.03.05.0270.000423%Not Available
Epigastric discomfort07.01.02.0040.000066%Not Available
Musculoskeletal discomfort15.03.04.0010.000449%Not Available
Inappropriate antidiuretic hormone secretion05.03.03.001; 14.05.07.0010.000088%Not Available
Skin swelling23.03.03.0390.000044%Not Available
Secretion discharge08.01.03.0190.000044%Not Available
Tonsillar disorder22.04.05.0090.000550%Not Available
Limb deformity15.10.03.0040.000264%Not Available
Medical device discomfort08.07.01.0100.000132%Not Available
Nodule08.03.05.0020.000110%Not Available
Dental discomfort07.09.06.0020.000066%Not Available
Haemorrhoidal haemorrhage24.10.02.001; 07.15.03.0020.000088%
Vascular insufficiency24.04.02.0140.000044%Not Available
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