Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Autoimmune thyroiditis10.04.08.006; 05.02.04.0020.000066%Not Available
Labile hypertension24.08.02.0130.000066%Not Available
Osteopenia15.02.03.003; 14.04.04.0040.003817%Not Available
Oesophagitis ulcerative07.04.05.0030.000088%Not Available
Emotional distress19.04.02.0080.002642%Not Available
Allergic sinusitis22.04.06.003; 10.01.03.0210.000044%Not Available
Gingival ulceration07.09.13.0140.000066%Not Available
Tachyarrhythmia02.03.02.0080.000044%Not Available
Left ventricular dysfunction02.04.02.0110.000198%
Bradyarrhythmia02.03.02.0150.000044%Not Available
Left ventricular hypertrophy02.04.02.0140.000462%Not Available
Balance disorder08.01.03.081; 17.02.02.0070.000748%Not Available
Breast discomfort21.05.05.0070.000044%Not Available
Lumbar radiculopathy17.10.03.0030.000682%Not Available
Dysstasia15.03.05.011; 08.01.03.089; 17.02.02.012--Not Available
Intervertebral disc protrusion15.10.01.0040.001497%Not Available
Cerumen impaction04.01.01.0010.000484%Not Available
Ventricular hypokinesia02.04.02.0130.000066%Not Available
Hyposmia22.04.03.008; 17.04.04.0030.000066%Not Available
Musculoskeletal chest pain22.09.01.001; 15.03.04.0120.000898%
Deep vein thrombosis24.01.02.0030.001299%Not Available
Macular hole06.09.03.0090.000044%Not Available
Lacunar infarction17.08.01.016; 24.04.06.0090.000198%Not Available
Blood pressure inadequately controlled24.06.01.0070.000110%Not Available
Pulmonary calcification22.01.02.0190.000044%Not Available
Spondyloarthropathy15.01.09.0030.000044%Not Available
Facial paresis17.04.03.0020.000066%
Exercise tolerance decreased08.01.03.0360.000044%Not Available
Bile duct stenosis09.02.02.0010.000066%
Systemic inflammatory response syndrome24.06.03.008; 10.02.01.008; 08.01.05.0050.000044%Not Available
The 25th Page    First    Pre   25 26 27 28 29    Next   Last    Total 39 Pages