Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Retinopathy06.10.02.001; 24.03.07.0030.000044%
Rheumatoid arthritis15.01.03.001; 10.04.06.0010.001440%Not Available
Rhinitis allergic22.04.04.003; 10.01.04.0030.000726%
Rhinorrhoea22.12.03.0210.000176%
Rhonchi22.12.01.0130.000044%Not Available
Rosacea23.02.08.0010.000264%Not Available
Rotator cuff syndrome12.01.07.018; 15.01.08.0020.001629%
Sacroiliitis10.02.01.104; 15.01.01.0120.000176%Not Available
Sciatica17.10.03.001; 15.10.01.0010.001189%Not Available
Scleritis10.02.01.025; 06.04.07.0020.000044%Not Available
Scoliosis15.10.04.0010.001977%
Seborrhoeic dermatitis23.03.04.0180.000044%Not Available
Seborrhoeic keratosis23.10.01.008; 16.26.01.0080.000330%Not Available
Sedation17.02.04.0050.000132%Not Available
Sensory disturbance17.02.07.0060.000220%Not Available
Sensory loss17.02.07.0070.000132%Not Available
Sinus arrhythmia02.03.03.0080.000066%Not Available
Sinus bradycardia02.03.03.0090.000264%
Sinus congestion22.04.06.0010.000220%Not Available
Sinus headache22.12.03.022; 17.14.01.0020.000110%
Sinus tachycardia02.03.03.0100.000352%
Sjogren's syndrome15.06.01.015; 10.04.04.009; 07.06.01.010; 06.08.02.0110.000176%Not Available
Skin cancer23.08.02.002; 16.03.02.0020.000638%Not Available
Skin disorder23.03.03.0070.000198%Not Available
Skin lesion23.03.03.0100.000572%Not Available
Skin papilloma23.10.01.002; 16.26.01.002; 11.05.07.0010.000198%
Skin reaction23.03.03.013; 10.01.03.019--Not Available
Skin ulcer24.04.03.007; 23.07.03.0030.000418%
Sleep apnoea syndrome22.02.01.013; 19.02.05.002; 17.15.05.0010.001145%
Sleep disorder19.02.04.0010.000550%Not Available
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