Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acyclovir
Drug ID BADD_D00039
Description Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old.[L7321] Acyclovir was granted FDA approval on 29 March 1982.[L7318]
Indications and Usage For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox.
Marketing Status Prescription; Discontinued
ATC Code D06BB03; J05AB01; S01AD03
DrugBank ID DB00787
KEGG ID D00222
MeSH ID D000212
PubChem ID 135398513
TTD Drug ID D0B5MP
NDC Product Code 71209-006; 61919-530; 68071-4790; 65085-0039; 68071-2501; 60505-5306; 61919-370; 0395-8097; 65162-835; 71205-209; 63187-366; 63629-2327; 68071-2526; 65162-836; 71335-0225; 60505-5307; 71335-1013; 53002-2450; 63629-7975; 68382-992; 68071-1841; 71335-1381; 68071-2287; 71335-1111; 70771-1371; 66689-342; 68071-2506; 55700-835; 66673-002; 70934-373; 68382-792; 70934-512; 67296-1193; 70518-2518; 49711-0094; 70771-1082; 51927-2994; 68788-7575; 53002-0270; 68084-108; 71335-1645; 75834-124; 42291-017; 55700-651; 43063-340; 70771-1384; 63629-2009; 68071-2299; 70518-3306; 50090-0638; 69076-146; 72241-028; 70934-828; 66673-001; 68071-2247; 0093-3630; 16714-885; 63629-7639; 49452-0001; 51079-550; 71335-0695; 50383-810; 71335-1222; 61919-003; 62991-1004; 54348-627; 17856-0083; 63629-7636; 70771-1383; 50090-5610; 70518-1332; 69452-291; 70934-908; 75834-122; 67296-1185; 51407-146; 23155-227; 50090-3902; 62332-248; 50090-0645; 69117-0039; 71335-1290; 68788-7895; 50090-3250; 68382-126; 68071-5100; 53002-0082; 71205-578; 17337-0041; 23155-485; 50090-0644; 65841-802; 60505-0042; 50268-062; 43063-589; 70934-408; 65841-829; 68071-2488; 67296-1089; 50268-061; 0472-0082; 51672-1360; 17337-0005; 72275-733; 0713-0630; 68071-2408; 70934-354; 60760-652; 71209-004; 68071-4799; 71205-056; 70954-188; 55154-7629; 59651-493; 50090-3795; 68071-2235; 52935-0015; 71209-005; 70934-313; 67296-1707; 50090-5739; 68382-125; 12711-9744; 63187-574; 68788-7760; 65977-0058; 66267-399; 69988-0027; 23155-229; 63646-300; 45802-044; 70934-557; 63187-154; 67296-1625; 69132-001; 68071-2447; 38779-0173; 43063-928; 69117-0018; 58118-0791; 70518-2496; 46014-1017; 63629-2328; 71335-0323; 71205-472; 71205-243; 68084-107; 0378-9735; 69097-656; 0591-1159; 63629-9174; 60760-606; 68071-5094; 68071-5122; 61442-112; 70934-907; 43547-499; 52423-0906; 76420-050; 68084-109; 12711-9755; 71205-371; 67296-1108; 67296-1034; 13668-515; 70771-1081; 63187-253; 55154-4332; 71403-049; 63629-1678; 70518-2117; 68071-3222; 70518-3331; 68071-4528; 70518-0427; 0187-0994; 70934-697; 51927-0192; 71205-388; 71335-0280; 50090-0637; 68071-5006; 63629-7613; 51552-0671; 0143-9657; 51407-145; 70934-532; 72241-027; 63310-2090; 71335-0319; 70934-800; 68382-791; 65841-803; 71205-053; 31722-777; 75834-123; 70934-694; 0143-9658; 61442-113; 67296-1723; 70700-107; 69452-290; 50090-0596; 68462-746; 67296-0710; 55700-539; 65015-600; 46708-248; 63629-1006; 0904-5790; 53002-0083; 43063-826; 72241-026; 68382-049; 70934-465; 67296-1300; 53002-0271; 50090-0642; 31722-778; 60429-012; 70934-511; 0187-0993; 71335-1077; 50090-0643; 0168-0825; 68071-5157; 72578-002; 68382-048; 61919-331; 55700-786; 63629-1005; 71335-1757; 54348-624; 68071-2279; 72578-082; 71335-1053; 50090-0595; 71335-0470; 50090-3254; 63187-182; 67296-1543; 53069-0120; 50090-1624; 0904-5789; 68788-7923; 0378-8712; 70934-131; 70518-2455; 71335-1284; 70934-491; 71205-391; 0378-8700; 69117-0019; 61442-114; 72189-232; 23155-228; 33342-439; 63187-192; 76003-0010; 70934-556; 70934-401
Synonyms Acyclovir | 9-((2-Hydroxyethoxy)methyl)guanine | Aciclovir | Acycloguanosine | Herpoviric | Aciclobeta | Aciclostad | Isavir | Laciken | Mapox | Maynar | Milavir | Opthavir | Supraviran | Viclovir | Vipral | Virax-Puren | Virax Puren | ViraxPuren | Virherpes | Virmen | Virolex | Virupos | Virzin | Wellcome-248U | Wellcome 248U | Wellcome248U | Zoliparin | Zovirax | Zyclir | Aciclovir Alonga | Alonga, Aciclovir | Acifur | Acipen Solutab | Solutab, Acipen | Acivir | Activir | Acyclo-V | Acyclo V | Acyclovir Sodium | Sodium, Acyclovir | Antiherpes Creme | aciclovir von ct | Avirax | Cicloferon | Clonorax | Cusiviral | Genvir | Herpetad | Herpofug | Herpotern | Aci-Sanorania | Aci Sanorania | Aciclovir-Sanorania | Aciclovir Sanorania | Acic
Chemical Information
Molecular Formula C8H11N5O3
CAS Registry Number 59277-89-3
SMILES C1=NC2=C(N1COCCO)N=C(NC2=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Neurological symptomMyelin basic proteinP02686T547616305245
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin disorder23.03.03.007--Not Available
Skin exfoliation23.03.07.003--Not Available
Skin necrosis23.03.03.0110.000313%Not Available
Somnolence19.02.05.003; 17.02.04.0060.000469%
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Stupor17.02.04.007; 19.02.05.004--Not Available
Swelling face23.04.01.018; 10.01.05.0180.000313%Not Available
Tachycardia02.03.02.007--Not Available
Thirst14.03.02.007; 08.01.09.021--Not Available
Throat irritation22.02.05.013; 07.05.03.0040.000313%Not Available
Thrombocytopenia01.08.01.0020.000626%Not Available
Thrombocytopenic purpura23.06.01.007; 01.08.01.003--Not Available
Thrombocytosis01.08.02.001--Not Available
Thrombophlebitis superficial24.01.02.002--
Thrombotic thrombocytopenic purpura01.08.01.005; 24.07.06.014; 23.06.01.011--
Tinnitus17.04.07.004; 04.04.01.0020.000469%
Toxic encephalopathy17.13.01.004; 12.03.01.0270.000782%Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.0060.000122%
Tremor17.01.06.002--
Type I hypersensitivity10.01.03.006--Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urethral disorder20.07.01.002--Not Available
Urinary retention20.02.02.0110.000938%
Urinary tract disorder20.08.01.001--Not Available
Urticaria23.04.02.001; 10.01.06.0010.000313%
Uveitis10.02.01.023; 06.04.03.003--
Vasculitis24.05.02.001; 10.02.02.006--
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.0070.000313%
Visual impairment06.02.06.0080.000469%Not Available
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