Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acitretin
Drug ID BADD_D00036
Description An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Indications and Usage Zouboulis CC: Retinoids--which dermatological indications will benefit in the near future? Skin Pharmacol Appl Skin Physiol. 2001 Sep-Oct;14(5):303-15.
Marketing Status Prescription; Discontinued
ATC Code D05BB02
DrugBank ID DB00459
KEGG ID D02754
MeSH ID D017255
PubChem ID 5284513
TTD Drug ID D05QDC
NDC Product Code 42291-088; 0145-0091; 17337-0004; 76055-0001; 71214-0668; 0093-1136; 0093-1135; 58159-058; 42794-081; 42794-080; 0093-1138; 0145-0090; 62147-0145; 42794-083; 42291-086; 71214-0667; 71214-0669; 0378-7020; 0115-1750; 0115-1751; 0115-1752; 71214-0698; 42291-087; 62147-0146; 0378-7023; 17337-0003; 59981-011; 0115-1753
Synonyms Acitretin | Etretin | Isoacitretin | Isoetretin | Ro 10-1670 | Ro 101670 | Ro-10-1670 | Ro101670 | 13-cis-Acitretin | Neotigason | Soriatane | Acitretin, (Z,E,E,E)-Isomer | Ro-13-7652 | Ro137652 | Ro 13-7652 | Ro 137652
Chemical Information
Molecular Formula C21H26O3
CAS Registry Number 55079-83-9
SMILES CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anorectal discomfort07.03.03.003--Not Available
Fasting26.01.02.001--Not Available
Candida infection11.03.03.021--
Immune thrombocytopenic purpura10.04.01.008; 01.08.01.0070.005728%Not Available
Excessive cerumen production04.01.01.004--Not Available
Liver function test increased13.03.01.044--Not Available
Malignant melanoma in situ23.08.01.004; 16.03.01.0040.005728%Not Available
Toxic goitre14.11.01.046; 05.02.02.0060.005728%Not Available
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