Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acitretin
Drug ID BADD_D00036
Description An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Indications and Usage Zouboulis CC: Retinoids--which dermatological indications will benefit in the near future? Skin Pharmacol Appl Skin Physiol. 2001 Sep-Oct;14(5):303-15.
Marketing Status Prescription; Discontinued
ATC Code D05BB02
DrugBank ID DB00459
KEGG ID D02754
MeSH ID D017255
PubChem ID 5284513
NDC Product Code 42291-088; 0145-0091; 17337-0004; 76055-0001; 71214-0668; 0093-1136; 0093-1135; 58159-058; 42794-081; 42794-080; 0093-1138; 0145-0090; 62147-0145; 42794-083; 42291-086; 71214-0667; 71214-0669; 0378-7020; 0115-1750; 0115-1751; 0115-1752; 71214-0698; 42291-087; 62147-0146; 0378-7023; 17337-0003; 59981-011; 0115-1753
Synonyms Acitretin | Etretin | Isoacitretin | Isoetretin | Ro 10-1670 | Ro 101670 | Ro-10-1670 | Ro101670 | 13-cis-Acitretin | Neotigason | Soriatane | Acitretin, (Z,E,E,E)-Isomer | Ro-13-7652 | Ro137652 | Ro 13-7652 | Ro 137652
Chemical Information
Molecular Formula C21H26O3
CAS Registry Number 55079-83-9
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acne23.02.01.001--Not Available
Acute myocardial infarction24.04.04.001; Available
Ageusia17.02.07.001; Available
Aggression19.05.01.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Alcohol abuse19.07.02.007--Not Available
Alcohol intolerance14.02.01.001--
Alcoholism19.07.02.001--Not Available
Angioedema23.04.01.001; Available
Anorectal disorder07.03.01.001--Not Available
Arthropathy15.01.01.0030.005728%Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Atrophic vulvovaginitis21.02.01.003--Not Available
Back pain15.03.04.005--
Balanoposthitis21.09.03.001--Not Available
Basal cell carcinoma23.08.02.001; Available
Basophil count increased13.01.06.002--Not Available
Benign intracranial hypertension17.07.02.001--Not Available
Bilirubin conjugated increased13.03.01.007--Not Available
Bleeding time prolonged13.01.02.002--Not Available
Blepharitis23.03.04.012; Available
Blindness17.17.01.003; Available
Blister23.03.01.001; Available
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