Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Aceclofenac
Drug ID BADD_D00021
Description Aceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies [A19667, A19668, A19670]. Aceclofenac potently inhibits the cyclo-oxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever. Aceclofenac belongs to BCS Class II as it possesses poor aqueous solubility [A19667]. It displays high permeability to penetrate into synovial joints where in patients with osteoarthritis and related conditions, the loss of articular cartilage in the area causes joint pain, tenderness, stiffness, crepitus, and local inflammation [A19666]. Aceclofenac is also reported to be effective in other painful conditions such as dental and gynaecological conditions [A19672]. In 1991, aceclofenac was developed as an analog of a commonly prescribed NSAID, [DB00586], via chemical modification in effort to improve the gastrointestinal tolerability of the drug. It is a more commonly prescribed drug in Europe.
Indications and Usage Indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
Marketing Status Not Available
ATC Code M01AB16; M02AA25
DrugBank ID DB06736
KEGG ID D01545
MeSH ID C056498
PubChem ID 71771
NDC Product Code Not Available
Synonyms aceclofenac | 2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid | Falcol | Falcol Difucrem | Clanza CR | Preservex | Biofenac | Sanein | Beofenac | Aital | Airtal Difucrem | Airtal | Bristaflam | Gerbin | Gerbin Difucrem
Chemical Information
Molecular Formula C16H13Cl2NO4
CAS Registry Number 89796-99-6
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Enuresis20.02.02.003; Available
Rash23.03.13.001--Not Available
Rubella11.05.18.001--Not Available
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