Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Abacavir sulfate
Drug ID BADD_D00010
Description Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir.
Indications and Usage For the treatment of HIV-1 infection, in combination with other antiretroviral agents.
Marketing Status Prescription
ATC Code J05AF06
DrugBank ID DB01048
KEGG ID D00891
MeSH ID C106538
PubChem ID 9843042
TTD Drug ID D0A4IJ
NDC Product Code 65015-640; 64980-405; 0378-4105; 68554-0063; 65571-0012; 65862-089; 65085-0024; 53104-7558; 68554-0032; 17337-0001; 61876-0718; 49702-222; 61187-010; 68084-021; 63379-049; 65862-256; 49702-221; 0904-6523; 51079-204
Synonyms abacavir | 1592U89 | abacavir sulfate | Ziagen | (1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol | abacavir succinate
Chemical Information
Molecular Formula C14H20N6O5S
CAS Registry Number 188062-50-2
SMILES C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.OS(=O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HypersensitivityHLA class I histocompatibility antigen, B alpha chainP01889Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nausea07.01.07.001--
Neutropenia01.02.03.004--Not Available
Neutrophil count13.01.06.046--Not Available
Pain08.01.08.004--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Platelet count13.01.04.011--Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Renal disorder20.01.02.002--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Sleep disorder19.02.04.001--Not Available
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Thrombocytopenia01.08.01.002--Not Available
Vomiting07.01.07.003--
Fat redistribution14.08.04.002--Not Available
Body fat disorder14.08.04.012--Not Available
Respiratory tract infection viral22.07.07.002; 11.05.04.003--Not Available
Hyperamylasaemia14.11.01.003--Not Available
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