| ADR Ontology |
| ADR Term |
Polyglandular autoimmune syndrome type II |
| ADR ID |
BADD_A10712 |
| ADR Hierarchy |
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| Description |
Autoimmune diseases affecting multiple endocrine organs. Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (CANDIDIASIS, CHRONIC MUCOCUTANEOUS), while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis (THYROIDITIS, AUTOIMMUNE;), HYPOPARATHYROIDISM; and gonadal failure. In both types organ-specific ANTIBODIES against a variety of ENDOCRINE GLANDS have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present. [MeSH] |
| MedDRA Code |
10036073 |
| MeSH ID |
D016884
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|
ADR Severity Grade (FAERS)
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|
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ADR Severity Grade (CTCAE)
|
Not Available
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| Synonym |
| Polyglandular autoimmune syndrome type II | Schmidt's syndrome | Autoimmune polyendocrine syndrome type II | Polyendocrinopathies, Autoimmune | Autoimmune Polyendocrinopathy | Polyendocrinopathy, Autoimmune | Polyglandular Type III Autoimmune Syndrome | Polyglandular Autoimmune Syndrome, Type 3 | Autoimmune Syndrome Type III, Polyglandular | Autoimmune Polyglandular Syndrome Type III | Autoimmune Polyglandular Syndrome, Type 3 | Polyglandular Type I Autoimmune Syndrome | APECED | APS Type 1 | Autoimmune Polyendocrinopathy Syndrome Type 1 | Autoimmune Polyendocrinopathy with Candidiasis and Ectodermal Dystrophy | Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy | Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy | Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy, Autoimmune | Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy | Autoimmune Polyglandular Syndrome Type I | Autoimmune Polyglandular Syndrome, Type 1 | Autoimmune Polyglandular Syndrome, Type I | Autoimmune Syndrome Type I, Polyglandular | Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy, Autoimmune | Polyendocrinopathy Candidiasis Ectodermal Dystrophy, Autoimmune | Polyglandular Autoimmune Syndrome, Type 1 | Polyglandular Autoimmune Syndrome, Type I | AIRE Deficiency | AIRE Deficiencies | Deficiency, AIRE | Polyglandular Type II Autoimmune Syndrome | Autoimmune Polyendocrine Syndrome, Type II | Autoimmune Polyglandular Syndrome Type II | Autoimmune Syndrome Type II, Polyglandular | Diabetes Mellitus, Addison Disease, Myxedema | Schmidt's Syndrome | Syndrome, Schmidt's | Multiple Endocrine Deficiency Syndrome, Type 2 | Polyendocrine Autoimmune Syndrome, Type II | Polyglandular Autoimmune Syndrome, Type 2 | Polyglandular Deficiency Syndrome, Type 2 | Schmidt Syndrome | Syndrome, Schmidt | Autoimmune Polyendocrine Syndrome, Type 2 | Diabetes Mellitus, Addison's Disease, Myxedema |
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| Drugs Leading to the ADR |
| Drug ID | Drug Name | ADR Frequency (FAERS) | ADR Severity Grade (FAERS) | | BADD_D01285 | Levothyroxine | 0.000007% | |
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