| ADR Ontology |
| ADR Term |
Holoprosencephaly |
| ADR ID |
BADD_A08240 |
| ADR Hierarchy |
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| Description |
Anterior midline brain, cranial, and facial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. Alobar prosencephaly is the most severe form and features anophthalmia; cyclopia; severe INTELLECTUAL DISABILITY; CLEFT LIP; CLEFT PALATE; SEIZURES; and microcephaly. Semilobar holoprosencepaly is characterized by hypotelorism, microphthalmia, coloboma, nasal malformations, and variable degrees of INTELLECTUAL DISABILITY. Lobar holoprosencephaly is associated with mild (or absent) facial malformations and intellectual abilities that range from mild INTELLECTUAL DISABILITY to normal. Holoprosencephaly is associated with CHROMOSOME ABNORMALITIES. [MeSH] |
| MedDRA Code |
10056304 |
| MeSH ID |
D016142
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
|
Not Available
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| Synonym |
| Holoprosencephaly | Holoprosencephalies | Semilobar Holoprosencephaly | Holoprosencephalies, Semilobar | Holoprosencephaly, Semilobar | Semilobar Holoprosencephalies | Lobar Holoprosencephaly | Holoprosencephalies, Lobar | Holoprosencephaly, Lobar | Lobar Holoprosencephalies | Alobar Holoprosencephaly | Alobar Holoprosencephalies | Holoprosencephalies, Alobar | Holoprosencephaly, Alobar | Holoprosencephaly, Familial Alobar | Arhinencephaly | Arhinencephalies |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
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| Drugs Leading to the ADR |
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