Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Sickle cell anaemia
ADR ID BADD_A03994
ADR Hierarchy
01      Blood and lymphatic system disorders
01.04      Haemoglobinopathies
01.04.02      Sickle cell trait and disorders
01.04.02.002      Sickle cell anaemia
03      Congenital, familial and genetic disorders
03.15      Blood and lymphatic system disorders congenital
03.15.03      Haemoglobinopathies congenital
03.15.03.001      Sickle cell anaemia
Description A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S. [MeSH]
MedDRA Code 10040641
MeSH ID D000755
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Anaemia sickle cell | HB-S disease without mention of crisis | Other sickle-cell anemia | Sickle cell anaemia | Sickle cell disease | Sickle cell disease NOS | Sickle cell disorders | Sickle-cell anaemia | Sickle-cell anemia | Sickle-cell anemia, unspecified | Drepanocytosis | Sickle cell anemia | Anemia sickle cell | Sickle-cell anaemia, unspecified | Anemia, Sickle Cell | Anemias, Sickle Cell | Sickle Cell Anemias | Hemoglobin S Disease | Disease, Hemoglobin S | Hemoglobin S Diseases | Sickle Cell Anemia | Sickle Cell Disorders | Cell Disorder, Sickle | Cell Disorders, Sickle | Sickle Cell Disorder | Sickling Disorder Due to Hemoglobin S | HbS Disease | Sickle Cell Disease | Cell Disease, Sickle | Cell Diseases, Sickle | Sickle Cell Diseases
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00100Ambrisentan0.003175%
BADD_D00162Arginine--
BADD_D00285Bosentan0.001118%
BADD_D00511Clozapine0.008407%
BADD_D00594Deferasirox0.032705%
BADD_D01336Macitentan0.002021%
BADD_D02018Sildenafil--
BADD_D02268Treprostinil0.000742%
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