Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Persistent foetal circulation
ADR ID BADD_A03388
ADR Hierarchy
02      Cardiac disorders
02.08      Congenital cardiac disorders
02.08.02      Congenital cardiovascular disorders NEC
02.08.02.001      Persistent foetal circulation
03      Congenital, familial and genetic disorders
03.07      Cardiac and vascular disorders congenital
03.07.01      Persistent foetal circulation disorders
03.07.01.002      Persistent foetal circulation
18      Pregnancy, puerperium and perinatal conditions
18.04      Neonatal and perinatal conditions
18.04.07      Neonatal cardiovascular disorders (excl cardiorespiratory arrest)
18.04.07.001      Persistent foetal circulation
24      Vascular disorders
24.03      Vascular disorders NEC
24.03.03      Vascular malformations and acquired anomalies
24.03.03.004      Persistent foetal circulation
Description A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT). [MeSH]
MedDRA Code 10034708
MeSH ID D010547
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Persistent foetal circulation | Newborn persistent pulmonary hypertension | Persistent fetal circulation | Persistent Fetal Circulation Syndrome | Pulmonary Hypertension, Familial Persistent, of the Newborn | ACD-MPV | ACD MPV | ACDMPV | Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins | Persistent Fetal Circulation | Circulation, Persistent Fetal | Familial Persistent Pulmonary Hypertension of the Newborn | Fetal Circulation, Persistent | Hypertension, Pulmonary, of Newborn, Persistent | Misalignment of the Pulmonary Vessels | Persistent Pulmonary Hypertension of Newborn | Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins And Other Congenital Anomalies
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00255Beractant--
BADD_D00475Citalopram0.000333%
BADD_D00809Escitalopram0.000025%
BADD_D00810Escitalopram oxalate--
BADD_D00932Fluoxetine0.001044%
BADD_D01242Lamivudine0.020870%
BADD_D01265Levetiracetam0.000381%
BADD_D01300Lisinopril--
BADD_D01498Morphine0.000122%
BADD_D01574Nitric oxide-
BADD_D01599Olanzapine0.002164%
BADD_D01679Paroxetine0.005048%
BADD_D01888Quetiapine0.000255%
BADD_D02010Sertraline0.000967%
BADD_D02346Venlafaxine0.000447%
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