| ADR Ontology |
| ADR Term |
Klinefelter's syndrome |
| ADR ID |
BADD_A02456 |
| ADR Hierarchy |
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| Description |
A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.). [MeSH] |
| MedDRA Code |
10023463 |
| MeSH ID |
D007713; D007713; D007713
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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Not Available
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| Synonym |
| Klinefelter's syndrome | XXY syndrome | Klinefelter Syndrome | Klinefelter Syndromes | Syndrome, Klinefelter | Syndromes, Klinefelter | XXY Syndrome | Syndrome, XXY | Syndromes, XXY | XXY Syndromes | Klinefelter's Syndrome | Klinefelters Syndrome | Syndrome, Klinefelter's | Klinefelter Syndrome, Variants | Klinefelter Syndromes, Variants | Syndrome, Variants Klinefelter | Syndromes, Variants Klinefelter | 48,XXYY Syndrome | Xxyy Syndrome | Syndrome, Xxyy | Syndromes, Xxyy | Xxyy Syndromes | XXY Trisomy | Trisomies, XXY | Trisomy, XXY | XXY Trisomies | 49,XXXXY Syndrome | XXXY Males | XXXY Male |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
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| Drugs Leading to the ADR |
| Drug ID | Drug Name | ADR Frequency (FAERS) | ADR Severity Grade (FAERS) | | BADD_D00419 | Cetrorelix | - | - | | BADD_D00420 | Cetrorelix acetate | - | - | | BADD_D00421 | Cetrorelix trifluoroacetate | - | - |
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